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Earliest modern human genomes constrain timing of Neanderthal admixture

PRJEB78725 Original Paper / DOI2024-12-124 samples (study)

AI interpretationAI-generated

45,000-year-old German genomes push back the shared Out-of-Africa split.

Researchers sequenced six genomes from Ranis, Germany (about 45,000 years old) plus another from Zlatý kůň, Czechia. These people were close relatives belonging to one small, isolated group. Their DNA shows they represent the deepest known split among all non-African lineages, and it carries Neanderthal segments from a single admixture event dated to roughly 45,000-49,000 years ago.

Sample interpretation

The site lists 4 ancient samples: 3 from Ranis (labeled 45000) and 1 from Zlatý kůň (ZKU002). Y-chromosome resolution is available for 3 samples, all falling under K-FTH1. Mitochondrial DNA is resolved for 3 samples: two belong to haplogroup N and one to N-T16172C. These small numbers reflect the limited but high-quality ancient genomes analyzed in this study.

For genealogy enthusiasts

For ancestry fans, this means all present-day non-Africans trace back to a single population that lived around 45,000-49,000 years ago, and that some earlier European fossils belong to separate, now-extinct branches. It also pins the Neanderthal mixing event to a narrow time window.

Abstract

现代人类在 45,000 多年前抵达欧洲,与尼安德特人至少重叠了 5,000 年 1,2,3,4。这些早期现代人类的有限基因组数据显示,至少有两个基因上不同的群体居住在欧洲,以捷克的 Zlatý kůň3 和保加利亚的 Bacho Kiro2 为代表。在这里,我们通过分析来自德国拉尼斯 Ilsenhöhle 约 45,000 年历史的遗骸的一个高覆盖率基因组和五个低覆盖率基因组以及来自 Zlatý kůň 的另一个高覆盖率基因组来加深对早期现代人类的了解。我们发现远亲关系将拉尼斯和 Zlatý kůň 个体联系在一起,并且他们属于同一个小而孤立的群体,该群体代表了与非洲之外血统最深的已知分裂。拉尼斯基因组包含尼安德特人片段,这些片段源自与所有非洲以外人共同的一次混合事件,我们将其追溯到大约 45,000-49,000 年前。这意味着迄今为止测序的所有非洲以外人的祖先当时都生活在一个共同的人群中,并进一步表明来自非洲以外 50,000 多年前的现代人类遗骸代表了不同的非洲以外人群。

Samples & Data on TheYtree

4samples on site
3Y haplogroup resolved
2archaeological sites

Sample Map

Map tiles by TheYtree · dot size = number of samples

Paternal (Y-DNA) Haplogroups

HaplogroupSamples
K-FTH1 3

Maternal (mtDNA) Haplogroups

Sample Highlights More samples →

SampleY-DNAmtDNACulture / Period
RNI013 K-FTH1 N · 45000 BP
RNI087 K-FTH1 — · 45000 BP
RNI010 K-FTH1 N-T16172C · 45000 BP